Microtubule's Conformational Cap

Cell Structure and Function

Denis Chretien²  Imre Janosi³  Jean-Christophe Taveau²  Henrik Flyvbjerg¹ 

[1] Condensed Matter Physics and Chemistry Department, Riso National Laboratory, DK-4000 Roskilde, Denmark;Laboratoire des Proteines Complexes, Universite de Tours, 2 bis Boulevard Tonnelle, F-37032 Tours, France;Department of Physics of Complex Systems, Eotvos University, Pazmany Peter setany 1/A, H-1117 Budapest, Hungary

关键词: microtubule;    tubulin;    electron microscopy;    computer modelling;   

DOI  :  10.1247/csf.24.299

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(32)Cited-By(18)The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-Pi-liganded molecules, the so called “GTP-cap”. Here, we point-out that the elastic properties of the microtubule lattice cause a difference in stability between the elongating tubulin sheet and the completed microtubule wall. The implications of our observations for microtubule structure and dynamics are discussed.

【 授权许可】

Unknown