Translocation of HSP27 and MKBP in Ischemic Heart

Cell Structure and Function

Atsushi Suzuki²  Kazuki Harada¹  Shigeo Ohno²  Kazi M.A. Shama¹  Ken-ichi Yoshida¹  Toshihiko Aki¹  Yasuhisa Kamoda¹ 

[1] Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan;Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0004, Japan

关键词: HSP27;    MKBP;    translocation;    ischemia;    myofibril;    oxidative stress;   

DOI  :  10.1247/csf.24.181

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(23)Cited-By(24)HSP27 and MKBP translocate from the cytosolic to myofibril fraction in ischemic rat heart as demonstrated by immunoblotting. Immunohistochemistry analysis showed that ischemia enhances the Z line labeling of HSP27 and MKBP. Two dimensional gel electrophoresis showed that ischemia increases the hyperphosphorylated form of HSP27. These data suggest that HSP27 and MKBP may be involved in the Z line protection against postischemic reperfusion injury.

【 授权许可】

Unknown