Signaling toward Yeast 1, 3-β-glucan Synthesis

Cell Structure and Function

Shunsuke Ben Inoue²  Yoshikazu Ohya¹  Yasuhiro Anraku¹  Takahide Watanabe²  Hiroshi Qadota¹  Mikio Arisawa² 

[1] Department of Biological Sciences, Graduate School of Science, University of Tokyo;Department of Mycology, Nippon Roche Research Center

关键词: yeast;    cell wall;    1;    3-β-glucan synthase;    rho GTPase;    geranylgeranyltransferase I;    plasma membrane invagination;   

DOI  :  10.1247/csf.21.395

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(62)Cited-By(13)1, 3-β-glucan synthase catalyzes the synthesis of a l, 3-/9-linked glucan polymer which produces the main rigidity of the yeast cell wall. Recent success in purification of this enzyme by product entrapment (21) has provided new insights into the dynamic aspects of the cell wall. This relatively simple procedure made it possible to identify the genes encoding the catalytic subunits of glucan synthase. In addition, the involvement of a rho type GTPase in the regulation of glucan synthase was demonstrated with the purified enzyme. Based on intracellular localization of the glucan synthase subunits, we have proposed a model in which assembly of the subunits is important for the activation of glucan synthase at sites of polarized growth. In this article, we will focus on biochemistry of 1, 3-β-glucan synthase and signaling through rho type GTPase.

【 授权许可】

Unknown