Protease-sensitive Component(s) on the Cell Surface Prevents Self-fusion in a Bisexual Strain of Dictyostelium discoideum

Cell Structure and Function

Kazuhiro Aiba¹  Hideko Urushihara¹ 

[1] University of Tsukuba, Institute of Biological Sciences

关键词: Dictyostelium discoideum;    sexual cell fusion;    cell recognition;    self-incompatibility;   

DOI  :  10.1247/csf.21.41

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(30)Cited-By(4)The sexual cycle of the cellular slime mold Dictyostelium discoideum offers a suitable system to analyze the mechanism of cell recognition during mating. Sexual cell fusion in D. discoideum typically occurs between complementary heterothallic strains. In addition, several bisexual strains are known which undergo sexual cell fusion with heterothallic strains of either mating type, but cannot do so by themselves. In the present study, trypsin digestion of cell surface molecules was found to induce self-fusion in a bisexual strain WS2162, suggesting the presence on the cell surface of a self-recognition molecule whose homophilic interaction interferes with the cell fusion mechanism.

【 授权许可】

Unknown