Flavonoids Inhibit the Expression of Heat Shock Proteins

Cell Structure and Function

Mitsunori Yoshida¹  Ydhei Hosokawa³  Kazuhiro Nagata²  Akira Nakai²  Nobuko Hosokawa¹  Akira Aoike¹  Hoyoku Nishino⁴  Nobuyuki Marui¹  Toshiyuki Sakai¹  Kazunori Hirayoshi²  Keiichi Kawai¹ 

[1] Department of Preventive Medicine, Kyoto Prefectural University of Medicine;department of Cell Biology, Chest Disease Research Institute, Kyoto University;Department of Pathology, Kyoto Prefectural University of Medicine;Department of Biochemistry, Kyoto Prefectural University of Medicine

关键词: flavonoids;    heat shock proteins;    human cancer cell lines;   

DOI  :  10.1247/csf.15.393

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(40)Cited-By(76)Cells exposed to several forms of stress, such as heat shock, transiently synthesize a group of proteins called heat shock proteins (hsps). Although many stressors other than heat shock are known to induce hsps, inhibitors of hsp expression have never been reported. Here we show that quercetiri and several other flavonoids inhibit the synthesis of hsps induced by heat shock in two human cell lines, Hela cells and COLO320 DM cells. Quercetin inhibited the induction of hsp70 at the level of mRNA accumulation. This is the first report to describe the inhibition of hsp expression by reagents.

【 授权许可】

Unknown