Controlled Production of Polymorphic Mixtures of MPPO in Batch Cooling and Drowning-Out Crystallization

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Youko Kiyosawa²  Yoshitaka Nakata²  Kooji Kagara²  Masakuni Matsuoka¹ 

[1] Department of Chemical Engineering, Tokyo University of Agriculture and Technology;Ohara Pharmaceutical Co., Ltd.

关键词: Production;    Crystallization Behavior;    Polymorphic Mixtures;    FBRM;   

DOI  :  10.1252/jcej.09We224

来源: Maruzen Company Ltd

【 摘 要 】

References(14)To obtain a desired polymorphic composition of MPPO (4-(1-(2-(3-methoxyphenethyl)phenoxy)-3-(dimethylamino) propan-2-yloxy)-4-oxobutanoic acid), operation conditions were sought for seeded and drowning-out batch crystallization. Polymorphic mixtures having the same composition with the seed were obtained by controlling the seeding temperature, because it determined the supersaturations for the crystallization of both polymorphs. Analyzing the changes in the solution concentration and monitoring the particle behavior with FBRM, different crystallization behaviors between the polymorphs were made clear.

【 授权许可】

Unknown