Microwave-Assisted Extraction of Protoberberine Alkaloids from Coscinium fenestratum

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Sachio Hirose¹  Makoto Suzuki¹  Nariaki Maeshibu¹  Phengxay Deevanhxay¹ 

[1] Department of International Development Engineering, Graduate School of Science and Engineering, Tokyo Institute of Technology

关键词: Microwave-Assisted Extraction;    Protoberberine;    Alkaloid;    Coscinium fenestratum;    Natural Product;   

DOI  :  10.1252/jcej.09we133

来源: Maruzen Company Ltd

【 摘 要 】

References(26)Cited-By(1)An effective method for the extraction of berberine (BER), palmatine (PAL), and jatrorrhizine (JAT) from Coscinium fenestratum by using microwave-assisted extraction (MAE) was developed in both an open (at atmospheric pressure) and closed vessel (under a pressurized condition). The extraction yields of BER yields obtained by using MAE under optimum conditions for 15 min (60% EtOH, material/solvent ratio 1.00 g:40 mL, microwave output power 300 W) in an open vessel at a boiling point of 83°C (25.20 mg/g) and in a closed vessel at 160°C (27.35 mg/g) were higher than those obtained using Soxhlet extraction for 8 h (24.37 mg/g) and extraction with 0.2% sulfuric acid for 24 h (21.82 mg/g). JAT (2.36 mg/g) and PAL (0.73 mg/g) extraction yields were observed to be the highest at 170°C for 15 min. Extraction using water as a solvent at 160°C for 15 min yielded the same level of BER amount (20.31 mg/g) as that obtained using 0.2% sulfuric acid for 24 h. This high extraction yield could be due to the alcohol-like characteristics of water at high temperature. BER degradation was observed at a temperature above 160°C. An additive such as EtOH or NaCl could reduce BER degradation. MAE is more effective than conventional extraction methods with regard to the extraction time and extraction yield for extracting protoberberine alkaloids from C. fenestratum.

【 授权许可】

Unknown