Control of the Barrier Capacity of Stratum Corneum by Microdermabrasion

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Tomohiro Hikima¹  Kakuji Tojo¹  Kohei Shirakami¹ 

[1] Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology

关键词: Stratum Corneum;    Peeling;    Transdermal Drug Delivery;    Microdermabrasion;   

DOI  :  10.1252/jcej.08we169

来源: Maruzen Company Ltd

【 摘 要 】

References(11)In microdermabrasion (MD), the stratum corneum (SC), which controls percutaneous absorption of drug molecules, is abraded and partly or completely removed by fine corundum powder under reduced pressure. The objective of this study is to evaluate the effect of MD on SC barrier capacity. Hairless mouse skin was treated by SkinCrystal, a MD system, with various operating vacuum powers (V) and treating duration (L). A matrix-type membrane device fabricated by ethylene vinyl-acetate (EVA) copolymer with drug was placed on the skin. The SC barrier capacity was examined by skin penetration experiment in vitro. The skin penetration flux increased with increasing V and L. The fraction of SC removed was defined by the following equation F = (fluxMD treated skin – fluxintact skin)/(fluxstripped skin – fluxintact skin), where F takes values within the range of 0 (intact skin) to 1 (stripped skin). For SkinCrystal, F is a function of V2 and L (F = 0.44V2L, r2 = 0.83). The SC barrier capacity is controlled with the parameters of the MD system, V and L.

【 授权许可】

Unknown