Crystallization of β-Sitosterol Using a Water-Immiscible Solvent Hexane

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Masaru Hirano¹  Koichi Igarashi¹  Hideo Kawachi¹  Hiroshi Ooshima¹  Rika Tanaka¹ 

[1] Graduate School of Engineering, Osaka City University

关键词: Crystallization;    β-Sitosterol Hemi-hydrate;    Morphology;    Pseudo-polymorph;    Hexane;   

DOI  :  10.1252/jcej.39.869

来源: Maruzen Company Ltd

【 摘 要 】

References(5)Cited-By(13)Cooling crystallization of β-sitosterol that is a kind of phytosterol was carried out, where a water-immiscible solvent hexane containing a ppm level of water was used as a solvent. The initial ratio of water and β-sitosterol concentration adopted in this work was 330/10, 1315/10 and 645/20 ppm/(g/L), which corresponded to 0.51, 2.0, and 0.50 in water/β-sitosterol mole ratio, respectively. When the initial ratio of water and β-sitosterol concentration was 1315/10 ppm/(g/L), thin plate-like crystals were precipitated and were identified as the monohydrate crystals of β-sitosterol. On the other hand, when the initial ratio of water and β-sitosterol concentration was 645/20 ppm/(g/L), needle-like crystals of hemihydrate were precipitated. This result meant that the ppm level of water plays an important role for the pseudo-polymorphism. Since the crystal structure of β-sitosterol hemihydrate had never been reported, we determined it by a single crystal XRD analysis.

【 授权许可】

Unknown