Scale-up Study on Unseeded Batch Cooling Crystallization Using Co-solvent

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Kwang-Joo Kim²  Choul-Ho Lee¹ 

[1] Department of Chemical Engineering, Kongju National University;Crystallization Process and Engineering Laboratory, Korea Research Institute of Chemical Technology

关键词: Cooling Crystallization;    Scale-up;    Crystal Size;    Spherulite;    Co-solvent;   

DOI  :  10.1252/jcej.35.1091

来源: Maruzen Company Ltd

【 摘 要 】

References(22)Cited-By(1)Crystallization using a co-solvent for producing spherical 3-nitro-1, 2, 4-triazol-5-one (NTO) crystals was carried out in two laboratory-scale and bench-scale crystallizers. The effect of scaling-up the crystallizers on the mean size of crystals of NTO during a batch cooling crystallization was explored. A simplified model based on the crystallization kinetics was established for the estimation of mean crystal size during the scaling-up of the crystallizer. Comparison of the crystals obtained from the laboratory-scale and from the bench-scale operations showed that the model can be successfully correlated with the mean crystal size. Eventually, the mean crystal size was estimated if the co-solvent composition was set optimally and the crystallizer scale-up was reasonable.

【 授权许可】

Unknown