A Mathematical Model of Internal Fouling in Protein Microfiltration

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Kazuho Nakamura¹  Kanji Matsumoto¹ 

[1] Department of Material Science and Chemical Engineering, Yokohama National University

关键词: Protein Adsorption;    Microfiltration;    Filtration Model;    Protein Fouling;    Adsorption Kinetics;   

DOI  :  10.1252/jcej.31.536

来源: Maruzen Company Ltd

【 摘 要 】

References(12)Cited-By(3)A mathematical model for internal fouling in protein microfiltration is developed to correlate flux decline and protein transmission with protein adsorption on pore surface during filtration. The model was constructed based on the mass balance of protein in a small section of membrane assuming that multilayer adsorption occurs in the pore, which consists of primary adsorption of proteins on the clean surface and the secondary one on the adsorbed protein. The flux decline is evaluated by a pore narrowing model which considers protein adsorption. The previously reported experimental curves of flux decline and protein transmission rate are fairly well simulated by this model using six fitting parameters, which are adsorption capacity, adsorption coefficient, and thickness of adsorption layer, in both the primary adsorption and the secondary adsorption.

【 授权许可】

Unknown