Enantioselective Permeation of Amino Acid Isomers through L-Phenylglycine-Fixed Membranes at Pressure Gradient

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Setsuji Tone¹  Satoshi Matsumoto¹  Teruyuki Masawaki¹ 

[1] Department of Chemical Engineering, Faculty of Engineering Science, Osaka University

关键词: Membrane Separation;    Optical Resolution;    Amino Acid;    Chiral Recognition;    Optical Isomer;   

DOI  :  10.1252/jcej.27.517

来源: Maruzen Company Ltd

【 摘 要 】

References(7)Cited-By(6)Three types of L-phenylglycine-rixed membranes were prepared by varying casting conditions. The optical resolution of racemic phenylglycine (DL-Pgly) was performed by pressure gradient. L-Pgly-fixed membranes were permeable in preference to D-Pgly to L-Pgly, and the maximum separation factors of respective membrane under the operating conditions were 9.1, 8.6 and 2.7. Apparent self-association constants were evaluated from the dialysis data. By applying these values to the basic solute flux equations at a given pressure gradient, the values of the viscous parameters were evaluated. The ratio of viscous parameter of D-Pgly to that of L-Pgly depended on the apparent self-association constant. The separation factor was successfully represented on the basis of the basic solute flux equations including the apparent self-association constants, and the separation factor became larger in denser membranes with low volume flux.

【 授权许可】

Unknown