Reactive Crystallization of Methyl α-Methoxyimino Acetoacetate

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

Masashi Momonaga¹  Hisatoyo Yazawa¹  Koji Kagara² 

[1] Manufacturing Technology, Laboratories, Fujisawa Pharmaceutical Co. Ltd.;Technological Development Laboratories, Fujisawa Pharmaceutical Co. Ltd.

关键词: Agitation;    Chemical Reaction;    Crystallization;    Mass Transfer;    Mixing;   

DOI  :  10.1252/jcej.25.237

来源: Maruzen Company Ltd

【 摘 要 】

References(7)Cited-By(1)Methyl α-methoxyimino acetoacetate, an intermediate of cephalosporin antibiotics, was produced through chemical reaction and crystallization. Because the crystal purity was influenced remarkably by both the chemical reaction and crystallization rates, high-purity crystals were obtained only by the optimum combination of the two rates. The effect of agitation on the chemical reaction rate and crystal quality was studied by consideration of mechanisms in reactive crystallization processes. It was confirmed that the Z factor, showing power consumption ratio of agitation, can be used to estimate crystal purity, yield, size distribution and scale-up effect for this reactive crystallization system.

【 授权许可】

Unknown