Nevirapine Hepatotoxicity: Case Report and Discussion

The Medicine Forum

Baichi, Matt¹ 

[1] Thomas Jefferson UniversityThomas Jefferson UniversityThomas Jefferson University

关键词: Thomas Jefferson University;    Drug-Induced Liver Injury/epidemiology;    Drug-Induced Liver Injury/virology;    Humans;    Incidence;    Liver/drug effects;    Liver/metabolism;    Nevirapine/adverse effects;    Risk Factors;   

DOI  :  

学科分类：医学（综合）

来源: Thomas Jefferson University

【 摘 要 】

Nevirapine (viramune) is a nonnucleoside reverse transcriptase inhibitor commonly used in combination with other antiretroviral medicines in the treatment of HIV/AIDS. The safety profile of nevirapine, as determined by review of prospective clinical trials, reports rash with an incidence of 16% as the most common side effect. Clinical hepatitis is reported to occur with an incidence of 1%. A review of the literature shows many case reports of nevirapine-induced hepatotoxicity in patients receiving both treatment and prophylaxis for HIV. The purpose of this case report is to stress the importance of early recognition and withdrawal of the offending drug.

【 授权许可】

Unknown