Lipid profile in acute viral hepatitis: A study from north eastern India

International Journal of Biomedical and Advance Research

Prasanta Kumar Bhattacharya¹  Rohan Dnyanoba Tomke¹  Hiranya Saikia¹ 

关键词: acute viral hepatitis;    serum lipids;    comparison;   

DOI  :  10.7439/ijbar.v7i8.3528

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Background:Acute viral hepatitis is associated with significant hepatic dysfunction including lipid metabolism. Variations in the serum lipid fractions in acute viral hepatitis due to hepatic injury may serve as prognostic marker for severity of hepatic injury.Methods:Hospital-based prospective study on acute viral hepatitis. Fifty cases of acute viral hepatitis and 50 age and sex matched controls, (>18 years) were studied. Routine biochemical investigation, hepatotropic viral serology and fasting serum lipid fractions were analysed for changes in patients with acute viral hepatitis. Chi-square test was used for comparing variables. A ?? value?<0.05 was considered statistically significant. Results:Baseline parameters were similar between cases and controls (p>0.05). Jaundice (100%) and high coloured urine (100%) were the commonest presentations. Hepatitis A virus (52%) and Hepatitis E virus (30%) were commonest aetiological agents. Serum cholesterol, triglycerides, low density lipoprotein (LDL) were significantly higher (p<0.01) while high density lipoprotein (HDL) was significantly lower (p<0.01) in acute viral hepatitis compared to controls. There was no statistically significant difference in the levels of very LDL between cases and controls (p>0.05). Complications were seen in 7 (14%) cases with hepatic encephalopathy being the commonest (6%). Serum cholesterol, triglycerides, LDL were significantly higher and HDL was significantly lower in hepatitis with complications compared to uncomplicated hepatitis (p<0.01). Conclusion:? Acute viral hepatitis leads to significant alterations of serum lipid fractions which may serve as an indicator of severity of liver damage and be helpful in assessing the prognosis of patients with acute viral hepatitis.

【 授权许可】

CC BY