Impact of Acute Lethal and Chronic Sublethal toxicity ofPhorateon Succinate Dehydrogenase activity in the Fresh Water Fish Cyprinus carpio

International Journal of Biomedical and Advance Research

Lakshmaiah Govindu¹ 

关键词: Phorate;    Succinate Dehydrogenase;    Acute lethal;    Chronic sublethal;    Cyprinus carpio;   

DOI  :  10.7439/ijbar.v7i4.3151

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

The present study is aimed to investigate the acute and chronic toxicity stress of phorate, induced alterations in the activity levels of Succinate Dehydrogenase (SDH), a vital enzyme of citric acid cycle that catalyses the reversible oxidation of succinate to fumarate. Freshwater fishCyprinus carpiowere exposed to acute lethal toxicity (LC 50 /96 hours - 0.71 ppm/l) of Phorate for one day and 4 days and chronic sublethal toxicity (one-tenth of the LC 50 /96 hours - 0.071 ppm/l) of Phorate for 1, 7, 15 and 30 days. After the completion of stipulated exposure period the SDH enzyme activity levels were estimated in the vital organs of fish such as gill, liver, muscle, kidney and brain. The activity of SDH in all the organs of the fish exposed to phorate decreased at 1 and 4 days of exposure in acute toxicity in the order, day 1>4. The decrease was more at day 4 than at day 1. In the fish exposed to chronic toxicity of phorate, in the activity of SDH from day 1 to day 7 there was increase in the decrement but from day 7 to day 30 it was regressed in all the organs of the fish in the order, day 1>7<15<30. The differences in the SDH activity between controls and experimental were found to be statistically significant (P<0.05). The present study indicates the phorate induced alterations in the activities of carbohydrate metabolic enzyme caused significant metabolic effect on the physiological consequences.

【 授权许可】

CC BY