Physicochemical characterization and solubility enhancement studies of Felodipin solid dispersions

International Journal of Biomedical and Advance Research

Sachin Nalavade¹  Audumbar Digambar Mali¹  Ritesh Bathe¹ 

关键词: Fast dissolving tablets;    Felodipine;    solvent evaporation method;    direct compression;    croscarmellose sodium.;   

DOI  :  10.7439/ijbar.v6i5.1929

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

The aim of present work is to develope fast dissolving tablets of Felodipine by first preparing solid dispersion with PEG 6000 and PVP K30 in ratio 1:1, 1:3 by direct compression method using different superdisintegrant such as crospovidone (CP), croscarmellose sodium (CCS). The prepared tablets were evaluated for pre-compression parameters such as angle of repose, bulk density, compressibility index, hausner?? ratio and post-compression parameters such as thickness, hardness, friability, drug content, weight variation, wetting time, water absorption ratio, In-Vitro disintegration time, in-vitro dissolution studies and stability studies. All the parameters showed good results. The study reveals that formulations prepared by direct compression F5 exhibits highest dissolution using croscarmellose sodium & showed faster drug release 99.89% over the period of 21 min. F5 batch disintigrate in 55 sec.show good disintegration? comparison to other formulations of Felodipine.?

【 授权许可】

CC BY