Delayed awakening after anaesthesia- A challenge for an anaesthesiologist

International Journal of Biomedical and Advance Research

Safiya Imtiaz Shaikh¹  Lakshmi R R¹ 

关键词: Delayed awakening;    General anaesthesia;    Drug effects;    Neuromuscular blockers;   

DOI  :  10.7439/ijbar.v5i8.829

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Delayed awakening from anaesthesia remains one of the biggest challenges that involve anaesthesiologists. Most commonly, delayed awakening is due to drugs effects persistence. 1 The time taken to emerge to fully consciousness is affected by patient factors, anaesthetic factors, duration of surgery and painful stimulation. Non pharmacological causes may have serious sequel; thus recognising these organic conditions is important. 2Unexpected delayed emergence after the use of general anaesthesia has a plethora of causes. 3The most common cause for delayed awakening following anaesthesia is medications and anaesthetic agents used in the perioperative period. There may be an over dose of medications. Emergence from anaesthesia depends on the tissue uptake of the drug, average concentration used and the duration of exposure. Certain underlying metabolic disorders such as hypoglycaemia, severe hyperglycaemia, electrolyte imbalance especially hyponatremia, hypoxia, hypercapnia, central cholinergic syndrome, chronic hypertension, liver disease, hypoalbuminemia, uraemia and severe hypothyroidism may also be responsible for delayed recovery after anaesthesia. Preoperative medications such as opioids and sedatives and hypothermia can further interfere with postoperative recovery. Intraoperative cerebral hypoxia, haemorrhage, embolism or thrombosis also can manifest as delayed awakening from anaesthesia.The ultimate goal of treatment is to find the cause and treat the cause, but primary management is to maintain airway, breathing and circulation.

【 授权许可】

CC BY