Comparative study of single dose pre-emptive pregabalin vs. Placebo for post-operative pain relief in middle ear surgery

International Journal of Biomedical and Advance Research

Hardik Khatri¹  Chetna A Jadeja¹  Vandana Parmar¹  Vrinda Oza¹ 

关键词: Pregabalin;    post-operative analgesia;    ear surgery;    VAS;   

DOI  :  10.7439/ijbar.v5i3.678

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Objectives:The present study was designed to evaluate effect of Pregabalin on pain scores and analgesic requirements in middle ear surgeries. Methods : ASA physical status I-III adults scheduled for elective middle ear surgery under general anesthesia were taken for study. Post-operative pain severity was assessed using VAS. Two study groups were designed. Group P (Study Group) received oral Pregabalin capsule (150 mg) while Group?? C (Control group) received oral placebo capsule one hour before surgery. The primary outcome was pain score in the recovery unit and patients were followed for 24 hours. Results:Pain scores were significantly lower in pregabalin group as compared to placebo group especially after 1 and 4 hours. More number of patients was sedated in pregabalin group compared to placebo. Conclusions:It can be concluded from our study that single dose preoperative pregabalin improves analgesia in early postoperative period and reduces analgesic consumption but with increased sedation without respiratory depression.

【 授权许可】

CC BY