Prognostic value of Serum C-Reactive Protein in Malaria

International Journal of Biomedical and Advance Research

Mitul Chhatriwala¹  Ruchi Gokani¹  Rita Shah¹  Nadeem Shaikh¹  Anup Nilawar¹  Bhavita Patel¹ 

关键词: C-Reactive Protein;    Malaria;    Plasmodium falciparum;    Plasmodium Vivax;    Prognostic marker;   

DOI  :  10.7439/ijbar.v5i10.912

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Introduction:C-Reactive protein is known as a marker of morbidity and mortality in malaria. It correlates closely with other complications in malaria and can be used to predict severity. Thus, measurement of CRP can be useful in understanding the pathogenesis of severe malaria. However, studies regarding CRP in malaria are very rare from India. Aims & objectives:The present study aimed to study CRP levels in patients with malarial infection and to find out the usefulness of CRP in assessment of disease severity. Material and Methods:The study population consisted of 50 patients with malarial infection, of them 29 werePlasmodium falciparum , 21 wereP. vivax -infected and no patient found with dual infection in our study. Out of 50 patients, 17 patients required admission for various reasons and of them 5 patients died. Serum C-reactive protein concentrations were measured in all the patients. Percentage parasitemia, platelet count and Liver function tests were measured on the day of admission. Statistical tests included were Students t-test, chi-square test and Pearson correlation coefficient. Results:Serum C-reactive protein concentration was significantly elevated in all the malaria patients and it was significantly higher (P<0.01) inPlasmodium falciparum(28.81 ? 10.91 mg/L) as compared toP. Vivaxmalaria (15.91 ? 8.73 mg/L ). Admitted patients had higher CRP levels (47.80 ? 12.73 mg/L) compared to patients treated on OPD basis (24.14 ? 12.17 mg/L) (P < 0.0001). Also CRP levels were higher in patients with multiple complications and in the patients who died compared to survivors. A significant positive correlation was found between serum CRP and percentage parasitemia, serum bilirubin, serum alanine aminotransferase and serum aspartate aminotransferase inP. falciparuminfected patients but not inP. Vivax . Conclusion:There is significant increase in C-reactive protein in malaria infected patients and can be considered a cost - effective and reliable tool in assessment of prognosis in malaria.

【 授权许可】

CC BY