A Study on Effect of Vitamin E as an Adjuvant to Metronidazole in Experimental Model of peritonitis

International Journal of Biomedical and Advance Research

Arjun Saxena¹  Dhananjaya Sharma¹  Pankaj Gharde¹  R K Jain¹  Deepak Shrivastava¹  Deepti Bala Sharma¹ 

关键词: : Peritonitis;    Experimental model;    Metronidazole;    Vitamin E;   

DOI  :  10.7439/ijbar.v4i12.577

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Introduction: The mortality is very high in cases of peritonitis; these cases are major burden in surgical wards, even after due care and use of higher broad spectrum antibiotics the mortality is high. Vitamin E is one of the antioxidant used widely. It inhibits of lipid peroxidation, reduces and neutralizes free radicals; this is what we call, ??he free radical scavenger effect.?The present study was carried out to assess the effect of intra-peritoneal Vitamin E and Metronidazole either singly or in combination, in experimentally produced faecal peritonitis model.puncture is satisfactory and gives good result. In our study the difference between Vitamin E group and Metronidazole group is very little and though Vitamin E scores better on most of the counts, the difference is too narrow for a justifiable definite conclusion to be safely drawn The antibiotic and antioxidant combination is superior to control group and to the antibiotic or antioxidant group when used alone.

【 授权许可】

CC BY