EVALUATING THE EFFECT OF WATER LOAD ON DIURNAL VARIATION OF CARDIOVASCULAR INDICES AND INTRAOCULAR PRESSURE IN HEALTHY SUBJECTS

International Journal of Biomedical and Advance Research

B. R. Doddamani¹  Mohammed Ehtesham Ali Farooqui¹  R. B. Patil¹ 

关键词: Diurnal Variation;    Intraocular Pressure;    Blood Pressure;    Heart Rate;   

DOI  :  10.7439/ijbar.v3i7.571

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Introduction : Ingestion of water increase the blood volume, followed by increased hydrostatic pressure, which in turn increases the intra ocular pressure.?? ??The mechanism of diurnal intra ocular pressure variation is uncertain. The present study evaluates the effect of water load on diurnal variation of cardiovascular indices and intraocular pressure in healthy subjects.Methodology:This study included 100 normal male healthy subjects from the Gulbarga city, recruited after their informed and written consent. IOP, HR, SBP, DBP, PP and MAP before and after water drinking test for 2hrs in the morning and evening was measured every 15minutes till 2hrs.Result:The change in IOP of right eye and left eye before and after water drinking test during early morning showed statistically significant (p<0.05) rise. A statistically significant (P<0.001) change of HR, SBP, DBP, PP and MAP in the morning and evening before drinking 1 liter of water was recorded.Discussion:The variation in the parameters studied may be due to combined effect of autonomic nervous system and release of glucocorticoids.?? conclusion: The intra ocular pressure fluctuation more than 30 mm Hg during diurnal variation of IOP and more than 8 mm Hg of IOP from pretreated value after drinking water has diagnostic value towards development of latent Glaucoma."

【 授权许可】

CC BY