High frequency audiometric study in cancer-cured patients treated with cisplatin

Revista Brasileira de Otorrinolaringologia

Moraes, Ilmara Fátima de¹  Associação Beneficente São Lucas¹  Umeoka, Waléria Gama¹  Pontifícia Universidade Católica de Campinas¹  Viera, Rafaela Corcelli¹  Almeida, Elizabeth Oliveira Crepaldi de¹ 

关键词: antineoplastic drugs;    audiometry;    cancer;    ototoxicity;   

DOI  :  10.1590/S0034-72992008000300012

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Hearing loss has been described in patients undergoing chemotherapy, given the ototoxic nature of these drugs. An audiological investigation is relevant in such cases. AIM: to assess audibility thresholds at high frequencies in individuals with cancer that was treated successfully with cisplatin and its associations, to verify possible hearing loss as a side effect of therapy. Site and date of the study: Campinas, Sao Paulo, in 2006. MATERIAL AND METHOD: Ten volunteers aged between 5 and 27 years were assessed by a clinical history, otoscopy, and conventional and high frequencies audiometry in this clinical and experimental study. RESULTS: A kappa coefficient statistical analysis revealed significant differences between ears in 50% of 14 frequencies that were evaluated. Eight participants presented hearing losses, which started at 1 kHz, increasing markedly at 6 kHz and above. Fisher's Exact Test revealed a significant association only with the dose and the right ear at high frequencies. CONCLUSION: It is possible that the hearing loss detected in this study is at least partially due to the ototoxicity of antineoplastic drugs; such loss may occur even after treatment is interrupted. We suggest that a protocol for audiological follow-up of patients undergoing chemotherapy should be created.

【 授权许可】

Unknown