Immunological evaluation of vestibular folds in autopsies of patients with the Acquired Immunodeficiency Syndrome

Revista Brasileira de Otorrinolaringologia

Rossi, Renata Calciolari¹  Universidade Federal do Triângulo Mineiro¹  Universidade Federal de Goiás¹  Teixeira, Vicente de Paula Antunes¹  Castro, Eumenia Costa da Cunha¹  Salge, Ana Karina Marques¹  Olegário, Janaínna Grazielle Pacheco¹  Corrêa, Rosana Rosa Miranda¹ 

关键词: autopsy;    vestibular folds;    aids.;   

DOI  :  10.1590/S0034-72992008000300009

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Immune response cells are decreased in patients with the Acquired Immunodeficiency Syndrome. This alters the cell population in vestibular fold lymphoid follicles, leading to respiratory infections in these patients. Such infections are the main cause of mortality and morbidity in these patients. AIM: to characterize lymphoid follicle cell populations in the vestibular folds of adults with the Acquired Immunodeficiency Syndrome and associated or not respiratory infection. MATERIALS AND METHODS: A retrospective study was made of 64 adult larynges harvested during routine autopsies. Anti-B cell, Anti-CD3, Anti-CD68 and Anti-follicular dendritic cell antibodies were used for immunological testing. RESULTS: 46 (71.87%) of the sample patients had the Acquired Immunodeficiency Syndrome. In these patients, lymphoid follicle cellularity was lower compared to the control group. The cell number was decreased in patients with the Acquired Immunodefficiency Syndrome and associated respiratory tract infection. CONCLUSION: We demonstrated in this study that vestibular fold lymphoid follicles were affected by viral infections, and may be considered as a reliable marker of immunodepression in these patients.

【 授权许可】

Unknown