Prognostic factors in the treatment of squamous cell carcinoma of the larynx: partial surgery x radical surgery

Revista Brasileira de Otorrinolaringologia

Hospital Heliópolis¹  Vidal, Maria da Graça Caminha¹  Abrahão, Marcio¹  Escola Paulista de Medicina de São Paulo¹  Hojaij, Flávio Carneiro¹  Cervantes, Onivaldo¹  Escola Paulista de Medicina¹  Amar, Ali¹  Universidade de São Paulo¹  Universidade Federal de Santa Maria¹ 

关键词: larynx;    surgery;    cancer;    prognosis;    survival;    treatment.;   

DOI  :  10.1590/S0034-72992007000600013

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

The present study aimed at assessing the other sites as the carcinoma spreads, as well as therapeutic results, in larynx preservation and patient survival. STUDY TYPE: It is a Longitudinal Historical Cohort Study, a retrospective clinical study. MATERIALS AND METHODS: A hundred and sixty (160) patients treated at 'Escola Paulista de Medicina' ('Paulista' Medical School) - São Paulo Hospital, from January 1988 to December 2004 were examined as for the spreading of their larynx carcinoma. Those patients whose evaluations were at least two years old after treatment were the only ones accepted. The parametric tests used were: Test X2, Fisher's test, and Kaplan-Meier's curve. RESULTS: The posterior commissure and the infraglottis were significant in terms of the laryngectomy: glottal tumors AC: (p=0.03) AP: (p=0.0001); AC: (p=0.0007) AP: (p<0.0001), respectively. The infraglottis was significant in G+SG tumors in AP: (p=0.04) and in death rate AP: (p=0.03). CONCLUSION: total laryngectomy is the treatment of choice in the presence of total involvement of the posterior commissure and the infraglottis. The latter may compromise survival, according to local invasion, even in the presence of free surgical margins.

【 授权许可】

Unknown