Radiation therapy and chemotherapy-induced oral mucositis

Revista Brasileira de Otorrinolaringologia

Volpato, Luiz Evaristo Ricci¹  Sakai, Vivien Thiemy¹  Oliveira, Thaís Marchini¹  Universidade de Cuiabá¹  Silva, Thiago Cruvinel¹  Universidade de São Paulo¹  Machado, Maria Aparecida Andrade Moreira¹ 

关键词: adverse effects;    mucositis;    chemotherapy;    radiotherapy.;   

DOI  :  10.1590/S0034-72992007000400017

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Tincreasing the intensity of radiation therapy and chemotherapy in the management of cancer has increased the incidence of adverse effects, especially oral mucositis. AIM AND METHODS: a bibliographical review was conducted on the definition of oral mucositis, its clinical findings, the incidence, its etiology, the pathofisiology, associated morbidity, prevention and treatment.RESULTS: current studies define oral mucositis as a very frequent and painful inflammation with ulcers on the oral mucosa that are covered by a pseudo membrane. The incidence and severity of lesions are influenced by patient and treatment variables. Oral mucositis is a result of two major mechanisms: direct toxicity on the mucosa and myelosuppression due to the treatment. Its pathofisiology is composed of four interdependent phases: an initial inflammatory/vascular phase; an epithelial phase; an ulcerative/bacteriological phase; and a healing phase. It is considered a potential source of life-threatening infection and often is a dose-limiting factor in anticancer therapy. Some interventions have been shown to be potentially effective to prevent and treat oral mucositis. Further intensive research through well-structured clinical trials to obtain the best scientific evidence over the standard therapy of oral mucositis is necessary to attain ideal parameters for radiotherapy and chemotherapy.

【 授权许可】

Unknown