"Hybrid" lesion of desmoplastic and conventional ameloblastoma: immunohistochemical aspects

Revista Brasileira de Otorrinolaringologia

Universidade Estadual de Feira de Santana¹  Sarmento, Viviane Almeida¹  De Souza, Veronica Ferreira¹  Universidade Estadual do Sudoeste da Bahia¹  Azevêdo, Roberto Almeida¹  Souza, Lélia Batista¹  Universidade Federal da Bahia¹  Santos, Jean Nunes dos¹  Universidade Federal do Rio Grande do Norte¹ 

关键词: ameloblastoma;    extracellular matrix;   

DOI  :  10.1590/S0034-72992006000500020

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Ameloblastomas are a common benign neoplasia of maxillary bones, originated from the remains of the dental plate. Histologically, it occurs in many patterns, including the types: follicular, plexiform, acanthomatous, of granular cells, of basal cells and the desmoplastic. The latter was initially described by Eversole et al.1, in 1984. It is usually characterized by a pronounced stroma collagenization, which is permeated by small islets and cords of the tumoral odontogenic epithelium. It also bears an uncommon radiographic aspect and a marked difference in anatomical location when compared to the conventional ameloblastoma.In recent years, the literature has described "hybrid lesions" of desmoplastic ameloblastoma and conventional ameloblastoma, that are microscopically characterized by presenting areas of follicular or plexiform ameloblastoma coexisting with areas of desmoplastic ameloblastoma2,3.Moreover, many studies have shown the importance of the extracellular matrix (ECM) in the modulation of neoplastic cell behavior and in the histomorphologic aspects of tumoral cells4. Thus, the present study aims at reporting a

【 授权许可】

Unknown