The role of cytokines in acquired middle ear cholesteatoma: literature review

Revista Brasileira de Otorrinolaringologia

Santa Casa de São Paulo¹  Ribeiro, Fernando de Andrade Quintanilha¹  Alves, Adriana Leal¹ 

关键词: immunohystochemistry;    cytokines;    middle ear;    cholesteatoma.;   

DOI  :  10.1590/S0034-72992004000600018

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

The present study conducted a critical analysis of the literature regarding the role of cytokines in acquired cholesteatomas. Middle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity revealing highly invasive properties evolving bone destruction and subsequent complications. Cytokines are low molecular weight-glycoproteins able to act in cellular intercommunication. They are important to stimulation and suppression of immune response-related events, triggering and coordinating inflammatory response, as well as wound healing and tissue remodeling. In cholesteatoma, reported cytokines and growth factors were as follows: IL-1, IL-6, IL-8, TNF-a, TGF-a, TGF-b, EGF and KGF. A synergism among different cytokines should occur to generate the aggressive characteristics of cholesteatoma.

【 授权许可】

Unknown