Oral squamous cell carcinoma - contribution of oncogenic virus and some molecular markers in the development and prognosis of the lesion: a review

Revista Brasileira de Otorrinolaringologia

Cabral, Márcia Grillo¹  Universidade Federal Fluminense¹  Lourenço, Simone de Queiroz Chaves¹  Universidade Federal do Rio de Janeiro¹  Venturi, Beatriz da Rocha Miranda¹ 

关键词: oral carcinoma;    telomerase;    oncogenic virus.;   

DOI  :  10.1590/S0034-72992004000300015

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Oral squamous cell carcinoma is a multistep event that continues to increase in incidence, particularly in the young, and to an extent that cannot be fully explained by increased exposure to known risk factors, as tobacco or alcohol. Recent molecular investigations suggest that there are multiple genetic events, and oncogenic virus that are able to alter the normal functions of oncogenes and tumor suppressor genes. The aim of the present article was to review the current knowledge on the role of Human papillomavirus (HPV), Epstein-Barr virus (EBV), P53 and telomerase in the development and prognosis of the oral squamous cell carcinoma.

【 授权许可】

Unknown