Revista Brasileira de Otorrinolaringologia | |
Oral candidiasis and hairy leukoplakia as progression markers of HIV infection in Brazilian patients | |
Cortina, Rodrigo Antonio Cataldo de la1  Lima, Adriana da Silva1  Universidade de São Paulo1  Miziara, Ivan Dieb1  | |
关键词: HIV; AIDS; oral candidiasis; hairy leukoplakia.; | |
DOI : 10.1590/S0034-72992004000300005 | |
学科分类:医学(综合) | |
来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial | |
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【 摘 要 】
Oral candidiasis (OC) and hairy leukoplakia (HL) are important markers of HIV (Human Imunodeficiency syndrome) infection progression for AIDS, mainly in locals where specific tests are inacessible.AIM: to intertwine OC and HL to CD4+ counting and to viral charge (VC) on HIV positive brazilian patients, confirming them as trustworthy clinical markers of the disease progression.STUDY DESIGN: Longitudinal cohort.MATERIAL AND METHOD: we have prospectively evaluated 124 HIV+ patients not in use of antiretroviral therapy. All of them have undertaken otorrhinolaringologic examination and CD4+ and VC counting, being divided in two groups: P and A, accordingly to presence or absence of OC and HL. After six months, patients belonging to the A group were re-divided on groups P6 (presence of lesions) and A6 (absence of lesions). Again, CD4+ and VC were counted. The results were statistically evaluated.RESULTS: on the P group, (43 patients, 28 OC, 15 HL) the CD4+ counting was smaller with greater viral charge when compared to A group (P<0.001). After 6 months, 15 of the 81 patients from the A group were excluded as they have initiated antiretroviral therapy. Eighteen patients (11 OC and 7 HL) were included on the P6 group. The others, who were free of lesions, were allocated on the A6 group. Again, CD4+ counting on the P6 group was smaller compared to the A6 group (P<0.001). The opposite occurred to the viral charge.DISCUSSION AND CONCLUSIONS: OC and HL indicate CD4+ counting below 300 cells/mm3 and increased VC, thus being trustable clinical markers of the disease progression.
【 授权许可】
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