Role of MT1-MMP in the Remodeling of the Periodontal Ligament During Tooth Movement

Revista clínica de periodoncia, implantología y rehabilitación oral

Universidad Finis Terrae, Chile¹  Smith Ferrer, P¹  Cruzat, F¹  Universidad Mayor, Chile¹  Pontificia Universidad Católica de Chile, Chile¹  Oyarzún Droguett, A¹  Rey Droghetti, P¹ 

关键词: MT1-MMP;    tissue remodeling;    periodontal ligament;    osteoclast;    tooth movement.;   

DOI  :  

来源: Sociedad de Periodoncia de Chile

【 摘 要 】

Tooth movement involves a series of changes of the supporting periodontal tissues characterized by the active connective tissue remodeling. MT1-MMP or MMP-14 belongs to the family of matrix metalloproteinases that are able to degrade type I collagen, the main molecule involved in periodontal attachment. Tooth migration requires the controlled degradation of periodontal ligament collagen fibers. However, evidences linking MT1 -MMP expression with periodontal tissue remodeling are lacking. In the present study, we have evaluated the expression of MT1-MMPand of the osteoclast marker Tartrate Resistant Acid Phosphatase (TRAP) in a model of tooth migration in rats. Tooth migration was induced after the insertion of a rubber band between the upper incisors. The distribution of TRAP and MT1 -MMP was evaluated by means of cytochemistry and immunohistochemistry respectively at days 1, 3, 5 and 7. TRAP production was identified in osteoclasts at the area of compression of the periodontal ligament. MT1-MMP distribution was observed in fibroblastsatthe compressed area of the periodontal ligament and also in osteoclasts of the same region. Our findings allow us to propose that MT1-MMP and TRAP take part of the tissue remodeling events observed during tooth movement.

【 授权许可】

Unknown