Physician preferences for bone metastasis drug therapy in Canada

Current Oncology

A. F. Mohamed¹  Y. Qian²  N. Califaretti⁵  J. Arellano²  J. Posner¹  A.B. Hauber¹  E. Chow⁶  M. Habib³  F. Gatta⁴  J.M. González¹ 

[1] RTI Health Solutions;Amgen;Amgen Canada;Amgen Europe;Grand River Regional Cancer Centre;Sunnybrook Health Science Centre

关键词: Bone metastases;    skeletal-related events;    physician preferences;    conjoint analysis;    discrete-choice experiments;    bone-targeted agents;   

DOI  :  

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

BackgroundCurrently in Canada, several bone-targeted agents (btas) with varying characteristics are available for the prevention of skeletal-related events (sres) in patients with bone metastasis secondary to solid tumours. In the present study, we evaluated the preferences of physicians in Canada for the various attributes of the available btas .MethodsPhysicians treating patients with bone metastasis from solid tumours were invited to complete an online discrete-choice experiment. Respondents were asked to choose between pairs of hypothetical medications for virtual patients. Each hypothetical medication was described based on predefined key attributes: time until first sre, time until worsening of pain, medication-related annual risk of osteonecrosis of the jaw (onj), medication-related annual risk of renal impairment, and mode of administration. A random-parameters logit model was used to analyze the choices between hypothetical medications and thus infer physician preferences for medication attributes. ResultsResponses from the 200 physicians who completed the discrete-choice experiment suggested that months until first sre, risk of renal impairment, and months until worsening of pain were considered the most important attributes affecting choice of bta. The annual risk of onj was considered the least important attribute. ConclusionsWhen making treatment decisions about the choice of bta for patients with bone metastasis from solid tumours, delaying sres and worsening of pain, and reducing the risk of renal impairment are primary considerations for physicians in Canada.

【 授权许可】

Unknown