Use of bevacizumab as a first-line treatment for metastatic breast cancer

Current Oncology

I. Calvo¹  F. Moreno⁴  P. Zamora¹  L. Manso⁵  B. Castelo²  S. Enrech¹  A. Arcediano¹  A.I. Ballesteros¹  E. López-Miranda¹  M. Martín-Angulo¹  M.J. Echarri¹  C. Olier¹  N. Martínez-Jañez¹  R. Márquez³  M. Arroyo¹  R. González del Val¹  A. Gómez¹ 

[1] Hospital Universitario La Paz;MD Anderson Cancer Center;Hospital Universitario Clínico San Carlos;Hospital Universitario 12 de Octubre

关键词: bevacizumab;    metastatic breast cancer;    clinical practice;   

DOI  :  

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

Objective During clinical practice, it can be challenging, given the lack of response biomarkers, to identify the patients with metastatic breast cancer (mbca) who would benefit most from the addition of bevacizumab to first-line standard chemotherapy. The aim of the present review was to summarize the relevant scientific evidence and to discuss the experience of a group of experts in using bevacizumab to treat mbca. Methods A panel of 17 Spanish oncology experts met to discuss the literature and their experience in the use of bevacizumab as first-line treatment for mbca. During the meeting, discussions focused on three main issues: the profile of the patients who could benefit most from bevacizumab, the optimal bevacizumab treatment duration, and the safety profile of bevacizumab. Results The subset of mbca patients who would benefit the most from the addition of bevacizumab to first-line standard chemotherapy are those with clinically defined aggressive disease. Treatment with bevacizumab should be maintained until disease progression or the appearance of unacceptable toxicity. In the mbca setting, the toxicity profile of bevacizumab is well known and can be managed in clinical practice after adequate training. Conclusions This expert group recommends administering bevacizumab as first-line treatment in patients with clinically aggressive disease.

【 授权许可】

Unknown