Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child

Current Oncology

L. Kren¹  J. Sterba²  K. Melicharkova¹  Z. Rehak²  R. Demlova³  H. Oslejskova¹ 

[1] University Hospital Brno;Masaryk Memorial Cancer Institute;Masaryk University School of Medicine

关键词: metronomic chemotherapy;    pet imaging;    biomarkers;    vinblastine;    pediatric glioma;   

DOI  :  

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

Background Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.

【 授权许可】

Unknown