Spontaneous regression of metastatic melanoma after inoculation with tetanus– diphtheria–pertussis vaccine

Current Oncology

D. Burt²  L. Eapen¹  T. Tran³  O.R. Keller¹ 

[1] Ottawa Regional Cancer Centre;Riverside Court Medical Clinic;The Ottawa Hospital

关键词: Melanoma;    regression;    fever;    tetanus;    vaccination;    cancer;    pertussis;    diphtheria;   

DOI  :  

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

Spontaneous regression of metastatic melanoma is an exceedingly rare event, with only 76 well-documented cases in the literature since 1866. Here, we present the case of a patient who developed metastatic melanoma despite interferon therapy and who then achieved spontaneous regression shortly after a reaction to tetanus–diphtheria–pertussis vaccination. A common theme among these cases is the development of febrile illness before remission of the malignant disease. A brief overview of proposed mechanisms for these miraculous recoveries is presented, including a highlight on the potential role of the herv-k-mel viral marker, a nona- or decapeptide that appears in most melanomas, with homologies to peptides in pathogenic microorganisms.

【 授权许可】

Unknown