SYNTHETIC STRATEGIES IN DRUG DISCOVERY: EMPLOYNG DIVERSITY-ORIENTED SYNTHESIS

Química Nova

Sangi, Diego Pereira¹  Universidade Federal Fluminense, Volta Redonda, Brazil¹ 

关键词:  target oriented synthesis;    diversity oriented synthesis;    drug discovery;   

DOI  :  10.5935/0100-4042.20160089

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Drug discovery often involves screening synthetic small molecules for their ability to bind to a macromolecular target. Target-Oriented Synthesis of a specific compound or a focused library can be planned combining retrosynthetic analysis and rational drug design. Biologically active molecules also can be identified through the unfocused screening of compound libraries. Diversity-Oriented Synthesis (DOS) emerges as an excellent strategy that leads to a library of structurally complex and diverse small molecules, covering a larger chemical space and increasing the probability of identifying modulators.

【 授权许可】

Unknown