3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties

Química Nova

Lemos, Elke M. F.¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brazil¹  Pereira, Marivalda M.¹  Centro Federal de Educação Tecnológica de Minas Gerais, Belo Horizonte, Brazil¹  Patrício, Patrícia S. O.¹ 

关键词:  porous scaffolds;    bioactive glass;    nanoparticles;    lyophilization;   

DOI  :  10.5935/0100-4042.20160047

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Porous synthetic substrates are developed through tissue engineering technologies to grow new tissue, restoring the function of tissue or an organ. For bone regeneration, these scaffolds must support the dynamic load exerted on this tissue, achieved primarily by increasing their compression strength, as established in the literature. The aim of this paper was to incorporate an inorganic composite bioactive glass (60%SiO2 - 36%CaO - 4%P2O5) as a reinforcing agent in mechanical 3D scaffolds that must remain porous. Two strategies were adopted: a co-precipitation method to obtain a nanoparticulate dispersion of bioactive glass (BGNP) and a sol-gel method to combine a bioactive glass solution (BG) with a previously prepared chitosan polymer solution. Moreover, a lyophilization process was also used, generating highly porous scaffolds. Various aspects of the scaffold were evaluated, including the morphology, orientation and size of the pores, and mechanical strength, as obtained using the two synthetic methods. The data for compressive strength revealed increased strength after the incorporation of bioactive glass, which was more pronounced when utilizing the nanoscale bioactive glass.

【 授权许可】

Unknown