SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW SERIES OF ORGANOTIN(IV) ESTERS WITH N,N-DIACETYLGLYCINE

Química Nova

Tabussam, Rukhsana¹  Ashfaq, Muhammad¹  Bahauddin Zakariya University, Multan, Pakistan¹  The Islamia University of Bahawalpur, Bahawalpur, Pakistan¹  Instituto Politécnico Nacional, Reynosa, Mexico¹  Shaheen, Salama¹  Ahmed, Muhammad Mahboob¹  Rivera, Gildardo¹ 

关键词:  N;    N-diethylglycine;    organotin(IV);    complexes;    antibacterial;    insecticide;   

DOI  :  10.5935/0100-4042.20150171

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A bioactive N,N-diacetylglycine (NNDAG) and new organotin(IV) complexes (OTCs) (1-7) were synthesized. Spectroscopic techniques were employed to characterize NNDAG and OTCs. FTIR was employed to verify N,N protection of glycine by acetyl groups. The disappearance of υ(OH) at 3000-2600 cm-1 showed de-protonation of free ligand. The Δυ 150<200 cm-1 of OTCs 4-7 verified bidentate coordination with tetrahedral geometry. The Δυ of OTCs1 and 3 was <200 cm-1 exhibitingtrans -octahedral geometry while OTC 2 dimer was assigned a unique sinusoidal view. The 1H NMR spectra of OTCs verified their synthesis by de-protonation of NNDAG and no chemical shift was found downfield for carboxylic acid proton. The 13C, 119Sn NMR and Mass spectrometric data also supported FTIR and 1H NMR descriptions. The OTCs 4, 5, 6 and7 (500 ppm) proved twice as active against Escherichia coli as the standard antibiotic enoxacin (1000 ppm). The promising property of the OTCs (4, 5, 6 and7) is clearly due to their tetrahedral. The OTCs 4and 5 exhibited excellent activity against M. minimum and good activity against T. castaneum.LD50 of all the compounds were determined and OTCs4, 5 and 7 were found to be active.

【 授权许可】

Unknown