PRELIMINARILY DEVELOPMENT OF A MOISTURE-ACTIVATED BIORESORBABLE POLYMERIC PLATFORM FOR DRUG DELIVERY

Química Nova

Kohn, Joachim¹  Dube, Koustubh¹  Universidade de São Paulo, Ribeirão Preto, BR¹  Freitas, Osvaldo de¹  Rutgers, Piscataway, US¹  Couto, Renê O. do¹  Sommerfeld, Sven D.¹ 

关键词:  drug delivery platform;    hydrolytically degradable polymer;    metronidazole;    plasticizer;    tyrosine-derived polymers;   

DOI  :  10.5935/0100-4042.20150118

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Bioresorbable polymeric films were prepared by solvent casting using a tyrosine-derived polycarbonate and metronidazole (MDZ) as the model drug at 2.5%, 5% and 10% (w/w). Drug loading did not affect the water uptake, drug release, polymer degradation or erosion profiles. All devices released approximately 85% (w/w) of the drug within a 1.5 h period. This may be attributed to the rapid water uptake of the polymer. An increase in the water uptake correlated with a linear rate increase of the polymer degradation (0.968 ≤ R2 ≤ 0.999). Moreover, MDZ presented a remarkable plasticizing effect for the polymer and drug loading exerted a significant impact on the mechanical properties of the obtained films. The results obtained can be used to further the development of novel biocompatible and biodegradable polymeric platforms for the delivery of metronidazole and other drugs in a broad range of pharmaceutical applications.

【 授权许可】

Unknown