FAST AND SIMULTANEOUS DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM USING BATCH INJECTION ANALYSIS WITH AMPEROMETRIC DETECTION AND BORON-DOPED DIAMOND ELECTRODE

Química Nova

Universidade Federal de Uberlândia, Uberlândia, BR¹  Muñoz, Rodrigo Alejandro Abarza¹  Richter, Eduardo Mathias¹  Silva, Weberson Pereira da¹  Pereira, Polyana Fernandes¹ 

关键词:  multiple pulse amperometry;    fast analysis;    simultaneous determination;    sulfamethoxazole;    trimethoprim;   

DOI  :  10.5935/0100-4042.20150059

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A fast, simple procedure for simultaneous determination of sulfamethoxazole (SMX) and trimethoprim (TMP) was performed using batch injection analysis with multiple pulse amperometric detection (BIA-MPA). The sample aliquot (150 µL) was directly injected onto the boron-doped diamond (BDD) electrode (wall-jet configuration) immersed in a BIA system. The analytical characteristics of the proposed method include high analytical frequency (up to 75 injections per hour), good stability (RSD < 2.9%; n = 10), low detection limits (0.227 and 0.173 mg L-1 for SMX and TMP, respectively) and minimal waste generation. The proposed method yielded similar results to those obtained by liquid chromatography at a 95% confidence level.

【 授权许可】

Unknown