SELECTIVE FLUORINATION METHODS OF ORGANIC MOLECULES

Química Nova

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil¹  Bastos, Mônica Macedo¹  Boechat, Núbia¹  Fundação Oswaldo Cruz, Manguinhos, Brasil¹  Pinto, Angelo da Cunha¹ 

关键词:  fluorine chemistry;    organofluorine;    electrophilic fluorination;    nucleophilic fluorination;   

DOI  :  10.5935/0100-4042.20150140

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Presently, the world depends on a wide variety of new materials based on organofluorine compounds. These compounds can be used as surfactants, high resistance polymers, liquid crystals, agrochemicals, radiopharmaceuticals for positron emission tomography, and drugs. However, the selective formation of C–F bonds remains a challenge. This study reviews our knowledge of organofluorine compounds and describes conventional and modern selective fluorination methods for obtaining these compounds. Here, we highlight the most common fluorination reagents and describe the fluorination reactions. This review is organized by the type of fluorine transfer: nucleophilic, electrophilic, and enzymatic

【 授权许可】

Unknown