Chemo-enzymatic epoxidation of β-caryophyllene using lipases immobilized in agar gel

Química Nova

Universidade Federal de Santa Catarina, Florianópolis, Brasil¹  Silva, Jaqueline M. R. da¹  Nascimento, Maria da Graça¹ 

关键词: immobilization;    agar gel;    epoxidation;    β;    -caryophyllene.;   

DOI  :  10.5935/0100-4042.20140171

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The immobilization of enzymes and microorganisms on solid supports has been developed in recent years. These biocatalysts may be used in organic media allowing their storage and reuse, thus reducing costs of the process. Herein, lipases from various sources were immobilized in agar gel and used as catalysts in the chemo-enzymatic epoxidation of β-caryophyllene. Several experimental parameters, such as the use of different organic solvents including ionic liquids, time, temperature, and agitation rate were evaluated. The mono-epoxide was obtained as a single product. The best result was achieved using immobilized F-AP15 lipase, forming the corresponding β-caryophyllene epoxide at a conversion of 96% in an 8h reaction at 35 ºC.

【 授权许可】

Unknown