Evaluation of chitosan microparticles containing curcumin and crosslinked with sodium tripolyphosphate produced by spray drying

Química Nova

Stulzer, Hellen Karine¹  Universidade Federal de Santa Catarina, Florianópolis, Brasil¹  Souza, Tereza Cristina Rozone de¹  Laranjeira, Mauro César Marghetti¹  Parize, Alexandre Luis¹  Universidade de Brasília, Planaltina, Brasil¹  Brighente, Inês Maria da Costa¹ 

关键词: chitosan;    curcumin;    spray drying.;   

DOI  :  10.1590/S0100-40422012000600011

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The aim of this study was to encapsulate curcumin into chitosan, using sodium tripolyphosphate (TPP) as an ionic crosslinker by the spray drying method. The influence of TPP on the properties of the final product, such as solubility, morphology, loading efficiency, thermal behavior, swelling degree and release profiles, was evaluated. The microparticles had a spherical morphology (0.5-20 µm) with no apparent porosity or cracks. Results indicated the formation of a polymeric network, which ensures effective protection for curcumin. Controlled-release studies were carried out at pH 1.2 and 6.8, to observe the influence of pH on curcumin release while the mechanism was analyzed using the Korsmeyer-Peppas equation.

【 授权许可】

Unknown