Synthesis and characterization of aba-type copolymers for encapsulation of bovine hemoglobin

Química Nova

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil¹  Lima, Felipe F.¹  Andrade, Cristina T.¹ 

关键词: bovine hemoglobin;    triblock copolymers;    encapsulation.;   

DOI  :  10.1590/S0100-40422012000500017

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The use of biopolymers for the development of oxygen carriers has been extensively investigated. In this work, three different ABA triblock copolymers were synthesized and used to encapsulate purified bovine hemoglobin, using a double emulsion technique. The effect of polymer composition, homogenization velocity, and addition of a surfactant, on the protein entrapment was evaluated. These copolymers, which have a hydrophilic block, achieved higher values of encapsulation efficiency than the corresponding homopolymers. The increase in homogenization strength also promoted an increase in encapsulation efficiency. Capsules formation occurred even in the absence of PVA.

【 授权许可】

Unknown