Synthesis of 2-azetidinone derivatives of 6-nitro-1H-indazole and their biological importance

Química Nova

Samadhiya, Pushkal¹  Sharma, Ritu¹  Gour University, Sagar, India¹  Srivastava, Santosh K.¹  Srivastava, S. D.¹ 

关键词: synthesis;    azetidinone;    biosignificance.;   

DOI  :  10.1590/S0100-40422012000500010

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A new series of 3-chloro-1-{[2-(6-nitro-1H-indazol-1-yl)ethyl]amino}-4-(substituted phenyl)-2-azetidinones (4a-j) was synthesized in four steps from 6-nitro-1H-indazole and characterized by IR, 1H NMR, 13C NMR, FAB-mass spectrometry and chemical methods. Compounds 4(a-j) were screened in vitro for their antibacterial, antifungal and antitubercular activities against some selected microorganism and for their antiinflammatory activity (in vivo) against albino rats (either sex). All above activities of compounds 4(a-j) showed acceptable results.

【 授权许可】

Unknown