An antimicrobial alkaloid and other metabolites produced by Penicillium sp. An endophytic fungus isolated from Mauritia flexuosa L. f.

Química Nova

Universidade Federal do Amazonas, Manaus, Brasil¹  Soares, Elzalina Ribeiro¹  Medeiros, Lívia Soman de¹  Souza, Afonso Duarte Leão de¹  Souza, Antonia Queiroz Lima de¹  Universidade do Estado do Amazonas, Manaus, Brasil¹  Almeida, Richardson Alves de¹  Koolen, Hector Henrique Ferreira¹  Silva, Felipe Moura Araújo da¹  Universidade Federal de São Carlos, São Carlos, Brasil¹  Rodrigues Filho, Edson¹ 

关键词: Penicillium;    Mauritia flexuosa;    glandicoline B.;   

DOI  :  10.1590/S0100-40422012000400022

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The alkaloid glandicoline B (1) and six other compounds: ergosterol (2), brassicasterol (3), ergosterol peroxide (4), cerevisterol (5), mannitol (6) and 1-O-α-D-glucopyranoside (7) were isolated from Penicillium sp. strain PBR.2.2.2, a fungus from Mauritia flexuosa roots. The structures of the isolated metabolites were established by spectral analysis. MeOH extract of the fungal mycelium at 500 µg mL-1 exhibited antimicrobial activity against Staphylococcus aureus and the compound 1 at 100 µg mL-1 was active against S. aureus, Micrococcus luteus and Escherichia coli. The relationship between the bioactive properties of the fungus PBR.2.2.2 and those achieved for glandicoline B, as well the potential of this substance as bactericide is discussed.

【 授权许可】

Unknown