Química Nova | |
Synthesis, antimicrobial and cytotoxic activities of 5-benzylidene-2-[(pyridine-4-ylmethylene)hydrazono]-thiazolidin-4-one and 2-[(pyridine-4-ylmethylene) hydrazono]-thiazolidin-4-one derivatives | |
Lima, José Gildo de1  Nascimento, Silene Carneiro do1  Rodrigues, Maria do Desterro1  Araújo, Janete Magali1  Alves, Antônio José1  Aguiar, Jaciana Santos1  Góes, Alexandre José da Silva1  Universidade Federal de Pernambuco, Recife, Brasil1  Silva, Teresinha Gonçalves1  Feitoza, Danniel Delmondes1  | |
关键词: 4-thiazolidinone; molecular hybridization; antimicrobial and cytotoxic activities.; | |
DOI : 10.1590/S0100-40422012000400007 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
A new series of 5-benzylidene-2-[(pyridine-4-ylmethylene)hydrazono]-thiazolidin-4-ones 4a-l have been synthesized. These compounds were designed by a molecular hybridization approach. 2-[(Pyridine-4-ylmethylene)hydrazono]-thiazolidin-4-ones 3a-d were also obtained and used as intermediates to give the target compounds. The in vitro antimicrobial and cytotoxic activities were evaluated for both series. The intermediate 3b showed considerable antibiotic activity against B. subtilis and C. albicans. In the cytotoxic activity compounds 3b (IC50= 4.25 ± 0.36 µg/mL) and 4l (IC50= 1.38 ± 0.04 µg/mL) were effective for inhibition of human erythromyeloblastoid leukemia (K-562) and human lung carcinoma (NCI-H292) cell lines, respectively.
【 授权许可】
Unknown
【 预 览 】
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RO201912050595674ZK.pdf | 320KB | download |