Knoevenagel condensation of aromatic aldehydes with Meldrum's acid in water: an experimental class on Green Organic Chemistry

Química Nova

Universidade Federal da Bahia, Salvador, Brasil¹  Cunha, Silvio¹  Santana, Lourenço Luis Botelho de¹  Universidade Federal da Bahia, Salvador¹ 

关键词: arylidene Meldrum's acid;    undergraduate organic chemistry experiment;    green chemistry.;   

DOI  :  10.1590/S0100-40422012000300036

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work describes an undergraduate experiment for the synthesis of Knoevenagel adduct of Meldrum's acid with nine aromatic aldehydes, using water as the solvent, in an adaptation of a previously reported synthetic protocol. The synthesis was straightforward, requiring a period of two hours, and is suitable for undergraduate experimental courses on green chemistry. In addition, quantitative analyses of the relative reactivity of p-nitro-benzaldehyde and p-metoxi-benzaldehyde was evaluated through the competitive reaction of equimolar amounts of these aldehydes with one equivalent of Meldrum's acid, using gas chromatography to quantify the composition of the reaction mixture.

【 授权许可】

Unknown