Thermodynamic study of the solubility of triclocarban in ethanol + propylene glycol mixtures

Química Nova

Universidad Nacional de Colombia, Bogotá, Colombia¹  Holguín, Andres R.¹  Delgado, Daniel R.¹  Martínez, Fleming¹ 

关键词: cosolvency;    solubility;    triclocarban.;   

DOI  :  10.1590/S0100-40422012000200009

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

By using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for triclocarban in ethanol + propylene glycol mixtures were evaluated from solubility data determined at temperatures from (293.15 to 313.15) K. The drug solubility was greatest in the mixture with 0.60 in mass fraction of ethanol and lowest in neat propylene glycol at almost all the temperatures studied. Non-linear enthalpy-entropy compensation is found indicating apparently different mechanisms of the solution process according to the mixtures composition.

【 授权许可】

Unknown