Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)

Química Nova

Hiramoto, Liliane L.¹  Universidade de São Paulo, São Paulo, Brasil¹  Tempone, André G.¹  Sartorelli, Patrícia¹  Pinto, Erika G.¹  Lago, João Henrique G.¹  Santos, Roberta T. dos¹  Universidade Federal de São Paulo, Diadema, Brasil¹  Instituto Adolfo Lutz, São Paulo, Brasil¹ 

关键词: Plectranthus barbatus;    1;    2;    3;    4;    6-penta-O-galloyl-β-D-glucose;    anti-trypanosomal activity.;   

DOI  :  10.1590/S0100-40422012001100025

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 µM, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature.

【 授权许可】

Unknown